The ORIGIN-FH Study

Welcome to the ORIGIN-FH Study. We’re glad you’re here! 

What is the ORIGIN-FH study? 

The Opportunity to Reach Individuals with Genetic Dyslipidemia during Infancy and the Newborn period to find Familial Hypercholesterolemia (ORIGIN-FH Study) is studying cholesterol levels in newborns at risk of having familial hypercholesterolemia (FH) during the first 2 years of life. Familial hypercholesterolemia (FH) is a genetic condition, which means it runs in families. FH causes high levels of cholesterol in the blood, especially a type called LDL cholesterol that is often called “bad” cholesterol.   

Screening for FH and learning about cholesterol levels during a baby’s first few years may help us diagnose and treat children earlier, leading to better health outcomes. Currently, FH is not routinely screened for newborns and young children, and we hope to change that! 

Who can participate? 

We’re looking for couples who:

• Are at least 12 weeks into their pregnancy AND
• One or both parents have been diagnosed with FH.

Aren’t sure if that describes you? Please reach out to us!  

Why participate? 

By joining this study, you may find out whether your baby has FH, which could benefit them directly. Parents may also learn about their own cholesterol levels, and how to use that information to improve their health care and possibly the health care of other family members. Most importantly, your participation may help others! As we learn more and improve how we identify FH in newborns, it could lead to better screening rates, fewer missed cases, and earlier treatment for babies and children with FH.